Resources

and FAQs

VOYXACT was designed to precisely block APRIL (A PRoliferation-Inducing Ligand). Blocking APRIL is one way to target the immune system activity of IgA nephropathy—as stated by the KDIGO guidelines.

VOYXACT is unique in multiple ways. First, VOYXACT is the only subcutaneous (under the skin) self-administered injection that is indicated for adults with primary IgA nephropathy at risk for disease progression. Second, it is the only medicine for IgA nephropathy that comes in a prefilled syringe. Third, it's self-injected once every 4 weeks. And lastly, it is the first and only FDA-approved treatment that selectively blocks APRIL.

The safety of VOYXACT was evaluated in 510 patients with IgA nephropathy. Side effects for people taking VOYXACT were similar to those on placebo (no active medicine). The most common side effects were upper respiratory infections and injection-site reactions. Most infections and injection-site reactions were mild to moderate and resolved without pausing or stopping treatment.

After your nephrologist prescribes VOYXACT, the specialty pharmacy that dispenses VOYXACT will contact you.

VOYXACT is only available from a specialty pharmacy. Specialty pharmacies work differently from traditional pharmacies. They ship your medicine directly to the address you provide. The specialty pharmacy for VOYXACT is called PANTHERx® Rare. PANTHERx Rare focuses solely on rare and orphan conditions like IgA nephropathy. They will call you to set up your shipments of VOYXACT.

Once you receive your VOYXACT prefilled syringe, be sure to keep it in the refrigerator (36 °F to 46 °F/2 °C to 8 °C) in its original box to protect it from light. Do not freeze, heat, or expose it to direct sunlight. Always keep VOYXACT—and all medicines—out of the reach of children.

Before injecting, let the prefilled syringe warm naturally to room temperature (up to 77 °F/25 °C). To get it to room temperature, let it sit out for 15–30 minutes before injecting. You can set a timer so you know when enough time has passed.
Once the VOYXACT prefilled syringe has reached room temperature, do not return it to the refrigerator.

Yes, it’s normal to see air bubbles. Do not try to remove them.

Do not use the VOYXACT prefilled syringe before injecting if:

• The liquid looks cloudy or discolored (it should look clear to opalescent, colorless to yellow)
• It has particles in it (it should look clear)
• The expiration date has passed
• It has been at room temperature for 7 days or longer
• Any part of the prefilled syringe is damaged
• The needle guard has been activated

If you can’t use the prefilled syringe because of any of these reasons, contact PANTHERx^® Rare by phone at 833-VOYXACT (869-9228), or use the PANTHERx Rare app. They will send you another VOYXACT prefilled syringe.

If you miss a dose, take the next dose as soon as possible, and then resume every 4 weeks after that.

Yes. Be sure to download the PANTHERx Rare app using one of these links:

Once you’ve been prescribed VOYXACT, you can use the PANTHERx Rare app for delivery coordination and refill requests. You can also contact PANTHERx Rare by phone at 833-VOYXACT (869-9228) Monday through Friday, 8 AM-8 PM ET
(except holidays).